Clopixol/Clopixol-Acuphase/Clopixol Depot may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. It should not be given concomitantly with guanethidine or similar acting compounds, since neuroleptics may block the antihypertensive effect of these compounds. Tricyclic antidepressants and neuroleptics mutually inhibit the metabolism of each other. Clopixol/Clopixol-Acuphase/Clopixol Depot may lower the effect of levodopa and adrenergic drugs. Concomitant use of metoclopramide and piperazine increases the risk of extrapyramidal symptoms.
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